کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376896 | 981967 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Chalcone derivatives 1–17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9–17, in which the sulfonyloxy group is placed on the A-ring. The 3′-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51 ± 0.05 μM) was the most potent K+ channel blocker.
Sulfonate Chalcones 9–17 were found to exhibit the potential to act as a new class of voltage-dependent K+ channel blockers.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 137–140
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 137–140
نویسندگان
Oleg V. Yarishkin, Hyung Won Ryu, Jae-Yong Park, Min Suk Yang, Seong-Geun Hong, Ki Hun Park,