کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376896 981967 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
چکیده انگلیسی

Chalcone derivatives 1–17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9–17, in which the sulfonyloxy group is placed on the A-ring. The 3′-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51 ± 0.05 μM) was the most potent K+ channel blocker.

Sulfonate Chalcones 9–17 were found to exhibit the potential to act as a new class of voltage-dependent K+ channel blockers.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 137–140
نویسندگان
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