کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376929 | 981967 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands](/preview/png/1376929.png)
A novel series of bis(pyrrol-2-yl-methyleneamine) ligands H2Ln (n = 1–4) were synthesized via condensation of diamines with two equivalents of 2-formyl-pyrrole (2). Their Zn(II) complexes were characterized by elemental analyses, mass spectra and IR spectra. The crystal structures of [ZnL1]2 and [ZnL4]2 obtained from ethanol solution was determined by X-ray diffraction analysis, each of them possesses a double-stranded helical geometry. In addition, the DNA-binding properties of the compounds have been fully investigated by absorption, fluorescence and viscosity measurements.
A novel series of bis(pyrrol-2-yl-methyleneamine) ligands H2Ln and their Zn(II) complexes were synthesized. The crystal structures of [ZnL1]2 and [ZnL4]2 show that each of them possesses a double-stranded helical geometry. In addition, the DNA-binding properties of the compounds have been fully investigated.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 298–303