Novel methylene-linked heterocyclic EP1 receptor antagonists

We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP1 receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound. Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.

The synthesis and biological activity of a series of novel methylene-linked heterocyclic EP1 receptor antagonists is described.Figure optionsDownload as PowerPoint slide