Structure-activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists

Potent and selective A3 adenosine receptor (AR) full antagonists with a nucleoside skeleton, of which the affinity and selectivity are independent of species, were discovered. Steric factors in the 5′ region were important in binding of nucleosides to the human A3AR.