Keywords: اتصال دهنده رادیولینگ; Radioligand binding; Mouse vas deferens; Opioid receptors; NOP receptor; Nociception; Bivalent ligands;
مقالات ISI اتصال دهنده رادیولینگ (ترجمه نشده)
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Keywords: اتصال دهنده رادیولینگ; Sigma receptor; Pulmonary pharmacology; Mouse; Radioligand binding;
Keywords: اتصال دهنده رادیولینگ; Pulmonary arterial hypertension; Endothelin; FR139317; Radioligand binding; Affinity constant; Receptor density;
In vitro pharmacology of ambroxol: Potential serotonergic sites of action
Keywords: اتصال دهنده رادیولینگ; Ambroxol; Radioligand binding; Serotonin; Receptor; 5-HT3; 5-HT transporter; SERT;
Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism
Keywords: اتصال دهنده رادیولینگ; Residence time; Structure-kinetics relationships; Cannabinoid 1 receptor; Insurmountable antagonism; Radioligand binding; Preincubation; Rimonabant (PubChem CID: 104850); CP55940 (PubChem CID: 104895); Antagonist 1 (CAS Registry Number: 1207203-10-8); Ant
Characterization of a nicotinic acetylcholine receptor binding site for sulfoxaflor, a new sulfoximine insecticide for the control of sap-feeding insect pests
Keywords: اتصال دهنده رادیولینگ; Sulfoxaflor (SFX); Isoclast⢠active; Radioligand binding; Sulfoximines; Myzus persicae (green peach aphid, GPA); Methyl-sulfoxaflor (Me-SFX);
[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement
Keywords: اتصال دهنده رادیولینگ; Adaptor-associated kinase 1; Neuropathic pain; Dorsal horn; Central nervous system; Radioligand binding; Occupancy; Rodent; Non-human primate;
Reevaluation of fenpropimorph as a Ï receptor ligand: Structure-affinity relationship studies at human Ï1 receptors
Keywords: اتصال دهنده رادیولینگ; SAFiR; Radioligand binding; 3D Molecular modeling; HINT analysis;
Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
Keywords: اتصال دهنده رادیولینگ; DL-1,4-Dithiothreitol (PubChem CID: 446094); Serotonin hydrochloride (PubChem CID: 160436); Clozapine (PubChem CID: 2818); Methysergide maleate (PubChem CID: 5281073); [3H]LSD (PubChem CID: 44559100); Serotonin 2A receptor; Phospholipase A2; Phospholipase
Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists
Keywords: اتصال دهنده رادیولینگ; LDL; low-density lipoprotein; HDL; high-density lipoprotein; cAMP; 3â²-5â²-cyclic adenosine monophosphate; SAR; structure-activity relationship; RLB; radioligand binding; GPCR; G-protein coupled receptor; BSA; bovine serum albumin; DCM; dichloromethane;
Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies
Keywords: اتصال دهنده رادیولینگ; Ap3A; diadenosine triphosphate; Ap4A; diadenosine tetraphosphate; Ap5A; diadenosine pentaphosphate; AR-C67085MX; 2-propylthio-β,γ-dichloromethylene-ATP; PSB0412; 2-propargylthio-β,γ-dichloromethylene-ATP; 5-BDBD; 5-(3-bromophenyl)-1,3-dihydro-2H-benzo
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples
Keywords: اتصال دهنده رادیولینگ; Sigma receptor; CNS; Decahydroquinoline; Radioligand binding; Structure-affinity relationship; Biology-oriented synthesis;
Characterisation of a novel, high affinity and selective αvβ6 integrin RGD-mimetic radioligand
Keywords: اتصال دهنده رادیولینگ; αvβ6; alpha-v beta-6; RGD; arginyl-glycinyl-aspartic acid; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DPU; Discovery Performance Unit; DMSO; dimethyl sulphoxide; ELISA; enzyme-linked immunosorbent assay; FCS; foetal calf serum; HE
Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia
Keywords: اتصال دهنده رادیولینگ; G-protein activation; [35S]GTPγS binding; Radioligand binding; Cannabinoid receptors; WIN-55,212-2 mesylate; Schizophrenia animal model;
Mild, Pd-catalyzed stannylation of radioiodination targets
Keywords: اتصال دهنده رادیولینگ; Stannylation; Radioiodination; Opioid; Sigma receptor; Radioligand binding
Prostacyclin receptor expression on platelets of humans with type 2 diabetes is inversely correlated with hemoglobin A1c levels
Keywords: اتصال دهنده رادیولینگ; Prostacyclin receptor; Platelet; cAMP; Type 2 diabetes; Radioligand binding; Western blot
Inhibition of in vivo [3H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice
Keywords: اتصال دهنده رادیولینگ; NMDA; GluN2B; Channel blocker; Antagonist; Radioligand binding; Occupancy
Subcellular localization and internalization of the vasopressin V1B receptor
Keywords: اتصال دهنده رادیولینگ; AVP; arginine-vasopressin; C-terminus; carboxyl-terminus; CHO; Chinese hamster ovary; DAB; 3,3â²-diaminobenzidine; DMEM; Dulbecco's modified Eagle's medium; GFP; green fluorescent protein; GPCRs; G-protein coupled receptors; HEK; human embryonic kidn
A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
Keywords: اتصال دهنده رادیولینگ; P2X7; Radioligand binding; Depression; Autoradiography; Receptor occupancy; JNJ-54232334; JNJ-54140515;
Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface
Keywords: اتصال دهنده رادیولینگ; Cys-loop receptor; Nicotinic acetylcholine receptor (nAChR); Ion channel; Pharmacology; Electrophysiology; Radioligand binding; ACh; acetylcholine; CRR; concentration response relationship; nAChR; nicotinic acetylcholine receptor; wt; wild-type; DPM; disi
Design, synthesis, pharmacological evaluation and molecular dynamics of β-amino acids morphan-derivatives as novel ligands for opioid receptors
Keywords: اتصال دهنده رادیولینگ; Morphans; Molecular dynamics; β-amino acids; Radioligand binding; μ opioid receptor;
Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors
Keywords: اتصال دهنده رادیولینگ; Pentamidine; NMDA receptor; Ifenprodil; Polyamine; Bisbenzamidine; Alkylation; Coupling; Radioligand binding; Rat brain; Molecular docking;
Characterization of [125I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta
Keywords: اتصال دهنده رادیولینگ; Cyclic AMP; Glucagon-like peptide 1 (GLP-1); Scintillation proximity assay; Radioligand binding; Vasoconstriction;
Extended N6 substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor
Keywords: اتصال دهنده رادیولینگ; G protein-coupled receptor; Purines; Molecular modeling; Structure activity relationship; Radioligand binding; Adenylate cyclase;
Cyclic ovarian hormone modulation of supraspinal Î9-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat
Keywords: اتصال دهنده رادیولینگ; Hormone; Female; Cannabinoid; Antinociception; Locomotion; Radioligand binding;
Agonists and antagonists induce different palonosetron dissociation rates in 5-HT3A and 5-HT3AB receptors
Keywords: اتصال دهنده رادیولینگ; Serotonin receptor; Allosteric binding site; Site-directed mutagenesis; Radioligand binding; FlexStation assays; 5-HT; 5-hydroxytryptamine (serotonin); HEK; human embryonic kidney; IC50; concentration of antagonist required for half-maximal inhibition; Kd
Exploring a potential palonosetron allosteric binding site in the 5-HT3 receptor
Keywords: اتصال دهنده رادیولینگ; 5-HT; 5-hydroxytryptamine (serotonin); EC50; concentration of agonist required for half-maximal response; HEK; human embryonic kidney; IC50; concentration of antagonist required for half-maximal inhibition; Kd; affinity constant; Serotonin receptor; Allos
The new radioligand [3H]-L 748,337 differentially labels human and rat β3-adrenoceptors
Keywords: اتصال دهنده رادیولینگ; [3H]-L 748,337; β3-Adrenoceptor; Radioligand binding; Rat urinary bladder
Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects
Keywords: اتصال دهنده رادیولینگ; Serotonin; Serotonin 5-HT2A receptor; Schizophrenia; Radioligand binding; Suicide; Postmortem human brain
Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist
Keywords: اتصال دهنده رادیولینگ; Prostacyclin analogues; Radioligand binding; Cyclic AMP; Calcium influx; Prostanoid receptors;
Adenosine A1 receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes
Keywords: اتصال دهنده رادیولینگ; Adenosine A1 receptor; Lipogenesis; Expression profiling; qPCR; Radioligand binding; Hepatocytes;
Analgesic, anticonvulsant and antioxidant activities of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride in mice
Keywords: اتصال دهنده رادیولینگ; Capsaicin; Writhing response; Maximal electroshock; Motor coordination; Trolox equivalent antioxidant capacity; Radioligand binding;
Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors
Keywords: اتصال دهنده رادیولینگ; Rimonabant; CB1 cannabinoid receptor; μ-Opioid receptor; [35S]GTPγS binding; Radioligand binding; Docking; CB1 receptor knockout mouse; CB1/CB2 receptor double knockout mouse; Forebrain;
Cloning and pharmacological characterization of the dog cannabinoid CB2 receptor
Keywords: اتصال دهنده رادیولینگ; Cannabinoid receptor; Cloning; Radioligand binding; Species selectivity; Pharmacology; GPCR; cAMP assay;
Novel nicotinic action of the sulfoximine insecticide sulfoxaflor
Keywords: اتصال دهنده رادیولینگ; Insecticide; Sulfoxaflor; Myzus persicae (green peach aphid); Nicotinic acetylcholine receptor; Radioligand binding; Electrophysiology;
Binding of “AT4 receptor” ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells
Keywords: اتصال دهنده رادیولینگ; AL-11; H-(R)-β2hVal-Tyr-Ile-His-Pro-β3hPhe-OH; AL-40; (R)-β2hVal-Tyr-Ile-Aia-Gly-Phe; Ang; angiotensin; AT4 receptor; type 4 angiotensin receptor; AP-N; aminopeptidase N; CHO-K1 cells; Chinese hamster overy cells; EDTA; ethylene diamine tetra-acetic ac
Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists
Keywords: اتصال دهنده رادیولینگ; Adenosine; A2AR; Combinatorial chemistry; GPCR; Radioligand binding; Parkinson’s disease; Thiazolopyrimidines
Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human α2-adrenoceptors: (+)8-OH-DPAT, but not (−)8-OH-DPAT is an α2B subtype preferential agonist
Keywords: اتصال دهنده رادیولینگ; (+)8-OH-DPAT; α2-adrenoceptor subtype; Radioligand binding; [35S]GTPγS binding; G protein coupled inwardly rectifying potassium channel
Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I107 variant of human neuropeptide S receptor
Keywords: اتصال دهنده رادیولینگ; Neuropeptide S receptor; Neuropeptide S peptide; Mutagenesis; Radioligand binding; Intracellular calcium
Pharmacological characterisation of the GlyT-1 glycine transporter using two novel radioligands
Keywords: اتصال دهنده رادیولینگ; Glycine transporter; GlyT-1; Radioligand binding; Rat brain; Human brainGlyT-1, glycine transporter type 1; hGlyT-1, recombinant human GlyT-1; NMDA, N-methyl-d-aspartate; HEK, human embryonic kidney; HEPES, N-2-Hydroxyethylpiperazine-N′-2-Ethanesulfonic A
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine
Keywords: اتصال دهنده رادیولینگ; Glutamate receptor; Marine natural product; Synthetic; Radioligand binding; Electrophysiology; Ligand-binding domain;
Young and older good learners have higher levels of brain nicotinic receptor binding
Keywords: اتصال دهنده رادیولینگ; Radioligand binding; Hippocampus; Temporal-parietal cortex; Trace eyeblink classical conditioning; Age differences;
Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats
Keywords: اتصال دهنده رادیولینگ; Curcumin; Glucose uptake; Muscarinic M1-cholinoceptors; Western Blot; Radioligand binding; Skeletal muscle; Wistar rat
Dielectric constants are not enough: Principal component analysis of the influence of solvent properties on molecularly imprinted polymer–ligand rebinding
Keywords: اتصال دهنده رادیولینگ; Chemometrics; Molecularly imprinted polymer; Molecular imprinting; Bupivacaine; Principal component analysis; Dielectric constant; Snyder polarity index; Radioligand binding
Binding sites of valsartan, candesartan and losartan with angiotensin II receptor 1 subtype by molecular modeling
Keywords: اتصال دهنده رادیولینگ; Binding sites; AT1 antagonists; Molecular modeling; Radioligand binding
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
Keywords: اتصال دهنده رادیولینگ; ATP; P2X7 receptor; IL-1beta; Gila; Radioligand binding; Pain; Inflammation; BzATP; 2â²(3â²)-O-(4-benzoylbenzoyl)adenosine 5â²-triphosphate triethylammonium salt; ATP; adenosine 5â²-triphosphate disodium salt; PPADS; pyridoxal phosphate-6-azophenyl-2â
Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse
Keywords: اتصال دهنده رادیولینگ; Senescence-accelerated mouse; Adenosine receptors; Aging; Brain; Radioligand binding
Characterization of human cannabinoid CB2 receptor coupled to chimeric Gαqi5 and Gαqo5 proteins
Keywords: اتصال دهنده رادیولینگ; Cannabinoid; hCB2; CB2 receptor agonist; Chimeric; G protein; Coupling; Radioligand binding; Calcium; G-protein coupled receptor
Activation of opioid μ-receptor by sinomenine in cell and mice
Keywords: اتصال دهنده رادیولینگ; Sinomenine; Opioid μ-receptor; Transfected cell; Radioligand binding; Receptor phosphorylation; Antinociception; Mouse
Human brain contains a novel non-AT1, non-AT2 binding site for active angiotensin peptides
Keywords: اتصال دهنده رادیولینگ; Brain angiotensin system; Angiotensin receptors; Gender; Parachloromercuribenzoate; Thiols; Radioligand binding