کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
868013 | 909800 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dielectric constants are not enough: Principal component analysis of the influence of solvent properties on molecularly imprinted polymer–ligand rebinding Dielectric constants are not enough: Principal component analysis of the influence of solvent properties on molecularly imprinted polymer–ligand rebinding](/preview/png/868013.png)
The influence of the physical properties of incubation medium on the rebinding of template to bupivacaine molecularly imprinted and non-imprinted methacrylic acid–ethylene dimethacrylate co-polymers has been studied. Principal component analysis (PCA) was employed to identify the factors with the greatest influence on binding. While the dielectric constant (D) made a significant contribution to describing the observed binding, the influence of polarity as reflected in the Snyder polarity index (SPI) was also demonstrated to make a significant contribution. The use of solvents containing hydroxyl functionality in particular was observed to exert unique effects on recognition. The variation in solvent influence on binding at constant D motivates more complex analyses when studying MIP–ligand recognition.
Journal: Biosensors and Bioelectronics - Volume 25, Issue 3, 15 November 2009, Pages 553–557