Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist

Differential activation of human prostanoid receptors expressed in cells: EC50 values for prostacyclin analogues treprostinil or iloprost in stimulating adenylate cyclase (causing vasodilatation - green) or calcium flux (causing vasoconstriction - red).