Novel nicotinic action of the sulfoximine insecticide sulfoxaflor

► Sulfoximines represent a new chemotype for the control of sap-feeding insects. ► Sulfoxaflor is the first sulfoximine insecticide under development. ► Sulfoxaflor is a very high efficacy agonist of Dα2/β2 nicotinic receptors. ► Sulfoxaflor is a weak inhibitor of [3H]imidacloprid binding. ► Sulfoxaflor may interact with nicotinic receptors differently than neonicotinoids.