کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377118 981971 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors
چکیده انگلیسی

A series of 8-aminomethylated derivatives (1a–1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their α-glucosidase inhibition activity against both yeast and rat intestinal α-glucosidase. Some of the compounds demonstrated significantly better α-glucosidase inhibitory activity than the parent compound (oroxylin A).

A series of 8-aminomethylated derivatives of oroxylin A were prepared by Mannich reaction and their α-glucosidase inhibition activities were studied.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 5, 1 March 2008, Pages 1659–1662
نویسندگان
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