کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377120 981971 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
چکیده انگلیسی

A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 5, 1 March 2008, Pages 1668–1673
نویسندگان
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