Keywords: مهار تلومراز; Naphthalene diimide derivatives; G-quadruplexes; Telomeric DNA; Double-stranded DNA; Telomerase inhibition;
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Arylsulfanyl groups - Suitable side chains for 5-substituted 1,10-phenanthroline and nickel complexes as G4 ligands and telomerase inhibitors
Keywords: مهار تلومراز; Phen; 5-substituted phenanthroline(s); Phen-Ni; 5-substituted phenanthroline and Ni2+ complexes; G4 ligands; G-quadruplex ligands; CD; circular dichroism; ESI; electrospray ionization; FID; fluorescent intercalator displacement; TRAP; telomeric repeat amp
A dinuclear copper(II) complex with piperazine bridge ligand as a potential anticancer agent: DFT computation and biological evaluation
Keywords: مهار تلومراز; UV–Vis, UV–Visible; CT DNA, calf thymus DNA; Tris, Tris(hydroxymethyl)aminomethane; EB, ethidium bromide; ITC, isothermal titration calorimetry; DFT, density functional theoryDFT computation; DNA binding studies; Telomerase inhibition; SOD mimics; Antitum
Attenuation of CCl4-induced hepatic oxidative stress in rat by Launaea procumbens
Keywords: مهار تلومراز; Carbon tetrachloride; Launaea procumbens; Liver histopathology; DNA fragmentations; Telomerase inhibition
Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis
Keywords: مهار تلومراز; Esophageal cancer; telomerase inhibition; ALT
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn2+ ions into its dipicolylamine groups
Keywords: مهار تلومراز; Naphthalene diimide; Hybrid-type G-quadruplex; Telomeric DNA; Zinc-dipicolylamine (Zn-Dpa) coordination complex; Telomerase inhibition;
Prevention of CCl4-induced nephrotoxicity with Sonchus asper in rat
Keywords: مهار تلومراز; Carbon tetrachloride; Sonchus asper; Histopathology; Renal function test; Antioxidant; Telomerase inhibition
Nanoparticle mediated delivery of 2′-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells
Keywords: مهار تلومراز; Telomerase activity; Telomerase inhibition; Telomere shortening; Non-small cell lung cancer; Nanoparticles; Antisense; Oligonucleotide
Telomerase as an emerging target to fight cancer — Opportunities and challenges for nanomedicine
Keywords: مهار تلومراز; Telomerase inhibition; Cancer therapy; G-quadruplex; Carrier system; Gene delivery; Nanoparticles
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
Keywords: مهار تلومراز; G-quadruplex; Telomere; Telomerase inhibition
Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation
Keywords: مهار تلومراز; Telomerase inhibition; Telomerase reactivation; Mouse cell line; Long telomeres; Dominant-negative TERT
Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives
Keywords: مهار تلومراز; Telomerase inhibition; Cytotoxicity; Anthraquinones; hTERT; G-quadruplex; SEAP assay; Telomerase assay; TRAP assay
Vitamin E suppresses telomerase activity in ovarian cancer cells
Keywords: مهار تلومراز; CDDP; cisplatin; FBS; fetal bovine serum; GFP; green fluorescent protein; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenol)-2-(4-sulfophenyl)-2H-tetrazolium; OSE; ovarian surface epithelial; PCR-ELISA; polymerase chain reaction enzyme-linked im
A model for triple helix formation on human telomerase reverse transcriptase (hTERT) promoter and stabilization by specific interactions with the water soluble perylene derivative, DAPER
Keywords: مهار تلومراز; DNA triple helix; Triplex forming oligonucleotide; Telomerase inhibition; hTERT promoter; Perylene derivative DAPER; Triplex and duplex-DAPER complexes;
Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol
Keywords: مهار تلومراز; Telomerase inhibition; Tocotrienol; hTERT; c-myc; Protein kinase C
Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model
Keywords: مهار تلومراز; Telomerase; Telomerase inhibition; Prostate cancer; Oligonucleotide; Docetaxel; Gene therapy;
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates
Keywords: مهار تلومراز; ANP; acyclic nucleoside phosphonate; ANPpp; ANP diphosphate; araGTP; 9-β-d-arabinofuranosylguanine 5â²-triphosphate; AZT-TP; 3â²-azido-3â²-deoxythymidine 5â²-triphosphate; CBV-TP; 2â²,3â²-didehydro-2â²,3â²-dideoxyguanosine 5â²-triphosphate; CdG-
Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: A dual mechanism approach
Keywords: مهار تلومراز; hTR; human telomerase RNA component; TP1; telomerase-associated protein 1; hTERT; human telomerase reverse transcriptase; PUFAs; polyunsaturated fatty acids; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; LDH; lactate dehydrogenase; PBS; phosphate