کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10583999 981314 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interactions of cyclic and non-cyclic naphthalene diimide derivatives with different nucleic acids
ترجمه فارسی عنوان
تعاملات مشتقات نفتالین دییمید سیکلی و غیر سیکلی با اسیدهای نوکلئیک مختلف
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Recently, strategy based on stabilization of G-quadruplex telomeric DNA by small organic molecule has been realized by naphthalene diimide derivatives (NDIs). At the same time NDIs bind to DNA duplex as threading intercalators. Here we present cyclic derivative of naphthalene diimide (ligand 1) as DNA-binding ligand with ability to recognition of different structures of telomeric G-quadruplexes and ability to bis-intercalate to double-stranded helixes. The results have been compared to non-cyclic derivative (ligand 2) and revealed that preferential binding of ligands to nucleic acids strongly depends on their topology and structural features of ligands.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 9, 1 May 2014, Pages 2593-2601
نویسندگان
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