کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377128 | 981971 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Transkarbams with terminal branching as transdermal permeation enhancers Transkarbams with terminal branching as transdermal permeation enhancers](/preview/png/1377128.png)
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
Series of Transkarbam 12 derivatives with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 5, 1 March 2008, Pages 1712–1715