کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377162 | 981972 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists](/preview/png/1377162.png)
چکیده انگلیسی
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6525–6528
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6525–6528
نویسندگان
Paul Galatsis, Koji Yamagata, John A. Wendt, Cleo J. Connolly, John W. Mickelson, Jared B.J. Milbank, Susan E. Bove, Christopher S. Knauer, Rachel M. Brooker, Corinne E. Augelli-Szafran, Roy D. Schwarz, Jack J. Kinsora, Kenneth S. Kilgore,