کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377283 981975 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrophilic acrylic hydrogels with built-in or pendant cyclodextrins for delivery of anti-glaucoma drugs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydrophilic acrylic hydrogels with built-in or pendant cyclodextrins for delivery of anti-glaucoma drugs
چکیده انگلیسی

Carbonic anhydrase inhibitors (CAIs) are gaining interest for local treatment of glaucoma and other ocular disorders. The aim of this work was to elucidate the role of cyclodextrins (CDs) in the loading and the release rate of acetazolamide (ACT) and ethoxzolamide (ETOX) from N,N-dimethylacrylamide-co-N-vinylpyrrolidone (DMA-co-NVP) hydrogels, suitable as high water-content soft contact lenses. Two different approaches to incorporate the CDs were evaluated: (i) synthesis of CD monomers and copolymerization with DMA and NVP; and (ii) grafting of natural CDs to preformed hydrogels. Natural β-CD and γ-CD were tested in each approach. The effects of the preparation method on relevant functional features of the hydrogels as well as on cytocompatibility and drug delivery performance were studied in detail. The role played by the CDs strongly depends on the physicochemical properties of the drug and its ability to form complexes; being particularly relevant for slightly soluble molecules that have high affinity for the CDs. Otherwise, unspecific interactions with the network may screen the contribution of the CDs.


► ACT and ETOX form inclusion complexes with β-CD and γ-CD.
► Acrylamidomethyl-CDs and grafted CDs did not alter relevant features of NVP-co-DMA as highly hydrophilic SCLs.
► Copolymerized/grafted CDs promote the uptake of slightly-soluble drugs with high CD-affinity constant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 88, Issue 3, 15 April 2012, Pages 977–985
نویسندگان
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