کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377409 981977 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors
چکیده انگلیسی

This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.

This manuscript describes the design and synthesis of a series of N-iso-propyl pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 16, 15 August 2007, Pages 4538–4544
نویسندگان
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