کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377436 | 981977 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists](/preview/png/1377436.png)
چکیده انگلیسی
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.
A combination of benzoxazole, phenoxyalkyl side chain and phenoxybutyric acids was identified as highly potent and selective h-PPARα agonists. The synthesis, SAR studies and in vivo activities of the representative compounds are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 16, 15 August 2007, Pages 4689–4693
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 16, 15 August 2007, Pages 4689–4693
نویسندگان
Yukiyoshi Yamazaki, Kazutoyo Abe, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Soichi Oda, Keisuke Inoue, Kimiyuki Shibuya, Bart Staels, Jean-Charles Fruchart,