کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377526 981981 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists
چکیده انگلیسی

We have recently reported the discovery of a novel class of glucocorticoid receptor (GR) antagonists, exemplified by 3, containing a 1,2-dihydroquinoline molecular scaffold. Further SAR studies of these antagonists uncovered chemical modifications conveying agonist functional activity to this series. These agonists exhibit good GR binding affinity and are selective against other nuclear hormone receptors.

The SAR study of novel class of glucocorticoid receptor agonist is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5091–5095
نویسندگان
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