کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377526 | 981981 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists](/preview/png/1377526.png)
چکیده انگلیسی
We have recently reported the discovery of a novel class of glucocorticoid receptor (GR) antagonists, exemplified by 3, containing a 1,2-dihydroquinoline molecular scaffold. Further SAR studies of these antagonists uncovered chemical modifications conveying agonist functional activity to this series. These agonists exhibit good GR binding affinity and are selective against other nuclear hormone receptors.
The SAR study of novel class of glucocorticoid receptor agonist is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5091–5095
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5091–5095
نویسندگان
Hidenori Takahashi, Younes Bekkali, Alison J. Capolino, Thomas Gilmore, Susan E. Goldrick, Paul V. Kaplita, Lisa Liu, Richard M. Nelson, Donna Terenzio, Ji Wang, Ljiljana Zuvela-Jelaska, John Proudfoot, Gerald Nabozny, David Thomson,