کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377559 981981 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics
چکیده انگلیسی

Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).

Some N-alkyl and N-aryl-substituted cyclic nitrones typified as 3 were designed with the help of PASS prediction, synthesized and evaluated pharmacologically as excellent nootropics/cognition enhancers.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5251–5255
نویسندگان
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