کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377638 981984 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyrazoloheteroaryls: Novel p38α MAP kinase inhibiting scaffolds with oral activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyrazoloheteroaryls: Novel p38α MAP kinase inhibiting scaffolds with oral activity
چکیده انگلیسی

A test library with three novel p38α inhibitory scaffolds and a narrow set of substituents was prepared. Appropriate combination of substituent and scaffold generated potent p38α inhibitors, for example, pyrazolo[3,4-b]pyridine 9, pyrazolo[3,4-d]pyrimidine 18a and pyrazolo[3,4-b]pyrazine 23b with potent in vivo activity upon oral administration in animal models of rheumatoid arthritis.

A test library with three novel p38α inhibitory scaffolds and a narrow set of substituents was prepared. Appropriate combination of substituents and scaffolds generated potent p38α inhibitors, for example, pyrazolo[3,4-b]pyridine 9, pyrazolo[3,4-d]pyrimidine 18a and pyrazolo[3,4-b]pyrazine 23b with potent in vivo activity upon oral administration in animal models of rheumatoid arthritis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 2, 15 January 2006, Pages 262–266
نویسندگان
, , , , , , , , , ,