کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377682 | 981984 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acryloylamino-salicylanilides as EGFR PTK inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of acryloylamino-salicylanilides were synthesized as inhibitors of EGFR PTK. A strategy of pseudo six-membered ring formed through intramolecular hydrogen bonding in salicylanilides is employed to mimic the planar pyrimidine ring of quinazoline EGFR inhibitors. Acrylamido moiety is incorporated to target the Cys-773 of EGFR specifically. Some of the obtained compounds exhibited good activity as EGFR inhibitors.
A series of EGFR PTK inhibitors with an acrylamido moiety at the 4- or 5-position of salicylanilides were synthesized and tested for their inhibitory activity toward the EGFR tyrosine kinase.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 2, 15 January 2006, Pages 469–472
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 2, 15 January 2006, Pages 469–472
نویسندگان
Wei Deng, Zongru Guo, Yanshen Guo, Zhiqiang Feng, Yi Jiang, Fengming Chu,