کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377698 981986 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H2SO4 in water
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H2SO4 in water
چکیده انگلیسی

In this investigation, a practical green chemistry procedure for synthesis of octahydroquinazolinone according to the Biginelli reaction using 5,5-dimethyl-1,3-cyclohexanedione, urea or thiourea, and appropriate aromatic aldehydes in the presence of two drops of concentrated H2SO4 as a catalyst is described in water. This methodology is of interest due to the use of water as a solvent without use of any organic solvent and toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution. Also this modified route provides much higher yields and simple work-up procedure of products.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 17, 1 September 2006, Pages 4479–4482
نویسندگان
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