کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377736 | 981986 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists](/preview/png/1377736.png)
Several tetrahydrofluorenones with a triazole fused across C7–C8 showed high levels of ERβ-selectivity and were found to be potent ERβ-agonists. As a class they demonstrate improved oral bioavailability in the rat over a parent class of 7-hydroxy-tetrahydrofluorenones. The most selective agonist displayed 5.7 nM affinity and 333-fold selectivity for ERβ.
Several tetrahydrofluorenones with a triazole fused across C7–C8 showed high levels of ERβ-selectivity and were found to be potent ERβ-agonists. As a class they demonstrate improved oral bioavailability in the rat over a parent class of 7-hydroxy-tetrahydrofluorenones. The most selective agonist displayed 5.7 nM affinity and 333-fold selectivity for ERβ.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 17, 1 September 2006, Pages 4652–4656