3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiaszolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDA MB468 cancer cells.Figure optionsDownload as PowerPoint slide