کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378123 | 981994 | 2005 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods](/preview/png/1378123.png)
Selectivity of enzymatic and chemical methods for transesterifications of cytarabine with divinyl dicarboxylates was described. Catalysis by lipase acrylic resin from Candida antarctica (CAL-B) in acetone facilitated the single step synthesis of polymerizable 5′-O-acyl cytarabine derivatives in high yields, while the use of alkaline protease from Bacillus subtilis (subtilisin) in pyridine afforded the mixture products of 5′-O-acyl and 4-N-acyl cytarabine derivatives. Interestingly, polymerizable 4-N-acyl cytarabine vinyl derivatives can be selectively prepared by chemical transesterification in dioxane. The obtained series of cytarabine derivatives would be useful for a significant monomer for a polymeric anticancer drug.
Selectivity of enzymatic and chemical methods for the synthesis of polymerizable cytarabine derivatives was described. The obtained series of cytarabine derivatives would be useful as a significant monomer for macromolecular anticancer drugs.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 18, 15 September 2005, Pages 4064–4067