Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure–activity, and biological results are presented.

This paper describes a novel class of anthranilic diamides with exceptional activity on insects of the order Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor.Figure optionsDownload as PowerPoint slide