کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378221 | 981996 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis](/preview/png/1378221.png)
چکیده انگلیسی
The synthesis of two caffeoyl-coumarin conjugates, derived from sagecoumarin, has been accomplished, starting from ferulic acid, isoferulic acid and sesamol. Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3′-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-β-gal-CD4+ cells.
Two caffeoyl-coumarin conjugates derived from sagecoumarin were synthesized and exhibited potent micromolar inhibitory potencies against HIV-1 integrase in 3′-end processing reaction but were less effective against HIV-1 replication.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 22, 15 November 2005, Pages 5053–5056
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 22, 15 November 2005, Pages 5053–5056
نویسندگان
Fabrice Bailly, Clémence Queffelec, Gladys Mbemba, Jean-François Mouscadet, Philippe Cotelle,