کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378253 | 981997 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists](/preview/png/1378253.png)
چکیده انگلیسی
Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.
Compound 11l exhibited potent in vitro activities in PPARα and γ (EC50 = 19, 13 nM). It showed better glucose lowering effect than rosiglitazone as well.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 937–941
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 937–941
نویسندگان
Hee Oon Han, Seung Hae Kim, Kyoung-Hee Kim, Gwong-Cheung Hur, Hyeon Joo Yim, Hee-Kyung Chung, Sung Ho Woo, Ki Dong Koo, Chang-Seok Lee, Jong Sung Koh, Geun Tae Kim,