کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378282 | 981997 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxic activities of 4,5-diarylisoxazoles
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively.
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized, and compounds 6d and 6e showed strong cytotoxicity against three human cancer cell lines.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1078–1081
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1078–1081
نویسندگان
Chang-Ming Sun, Lee-Gin Lin, Hsi-Jung Yu, Chih-Yu Cheng, Ya-Chuan Tsai, Chi-Wei Chu, Yi-Hui Din, Yat-Pang Chau, Ming-Jaw Don,