کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1378291 | 981997 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors](/preview/png/1378291.png)
A series of trifluoroacetophenone derivatives were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some of the ‘reverse amide’ analogs were found to be potent inhibitors of MCD enzyme activity. The trifluoroacetyl group may interact with the MCD active site as the hydrate in a similar fashion to the hexafluoroisopropanol analogs reported previously. Adding electron-withdrawing groups to the phenyl ring stabilizes the hydrated species and enhances this interaction.
A series of trifluoroacetophenone derivatives were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Several of the ‘reverse amide’ analogs were found to be potent inhibitors of MCD enzyme activity. The trifluoroacetyl group may interact with the MCD active site as the hydrate, which can be stabilized with electron-withdrawing groups.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1127–1130