Keywords: Malonyl-CoA; FapR; Biosensors; Fatty acid biosynthesis; Synthetic biology; Genetic circuits; Dynamic regulation;
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Keywords: Agouti-related peptide; Neuropeptide Y; Ghrelin; CPT1a; CPT1c; Malonyl-CoA
Keywords: Ghrelin; Hypothalamus; Malonyl-CoA; Carnitine palmitoyltransferase;
Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
Keywords: Acetoacetate pathway; Malonyl-CoA; Acetyl-CoA; Palmitate; Mass spectrometry; Mitochondrial biosynthesis; Citrate; ACC; acetyl-CoA carboxylase; ACLY; ATP citrate lyase; KIC; α-ketoisocaproic acid; SCOT; succinyl-CoA:3-ketoacid-CoA transferase; ZMP; 5-amin
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle
Keywords: BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; HF; high-fat; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PEMT; phosphatidylethanolamine N-methyltransferase; SREBP; sterol-regulatory element bindi
Rapid preparation of (methyl)malonyl coenzyme A and enzymatic formation of unusual polyketides by type III polyketide synthase from Aquilaria sinensis
Keywords: Meldrum's acid; Malonyl-CoA; Methylmalonyl-CoA; Type III polyketide synthase; Aquilaria sinensis;
Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products
Keywords: Antisense RNA; Malonyl-CoA; Fatty acid biosynthesis; 4-hydroxycoumarin; Resveratrol; Naringenin
Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae
Keywords: 3-hydroxypropionic acid; Saccharomyces cerevisiae; malonyl-CoA; NADPH;
Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte
Keywords: Ac-CoA; acetyl CoA; ACP; acyl carrier protein; DH; dehydrase; DMSO; dimethyl sulfoxide; ER; enoyl reductase; FAS; fatty acid synthase; FBS; fetal bovine serum; IC50; half-inhibitory concentration; KR; ketoacyl reductase; KS; ketoacyl synthase; Mal-CoA; ma
Research ArticleInhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
Keywords: PFT; pifithrin-α p-nitro; NAFLD; non-alcoholic fatty liver disease; HFD; high-fat diet; ALT; alanine aminotransferase; mCoA; malonyl-CoA; MLYCD; malonyl-CoA decarboxylase; LKB1; liver kinase B1; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase
Hypothalamic malonyl-CoA and the control of food intake
Keywords: Hypothalamus; Food intake; Malonyl-CoA; Carnitine palmitoyltransferase; Fatty acid;
Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus
Keywords: Streptomyces; Metabolic engineering; Glucose-1-phosphate; Malonyl-CoA; Antitumor; Production;
Effect of diet composition on coenzyme A and its thioester pools in various rat tissues
Keywords: Coenzyme A; Acetyl-CoA; Malonyl-CoA; Rats; Liver; CoA metabolism;
An analysis of the concentration change of intermediate metabolites by gene manipulation in fatty acid biosynthesis
Keywords: Acc, acetyl-CoA carboxylase; CoA, coenzyme A; Malonyl-[acp], malonyl-[acyl-carrier-protein]; FabD, malonyl-CoA:ACP transacylaseBiodiesel; Fatty acid biosynthesis; Intermediate metabolites; Acetyl-CoA; Acetyl-CoA carboxylase; Malonyl-CoA; Malonyl-CoA:ACP t
Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains
Keywords: 3-hydroxypropionic acid; Malonyl-CoA; Malonyl-CoA reductase; Acetyl-CoA carboxylase; Transhydrogenase; Chloroflexus aurantiacus
Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway
Keywords: Glucose-6-phosphate dehydrogenase; Streptomyces rimosus M4018; Oxytetracycline biosynthesis; NADPH generation; Malonyl-CoA
Development of Escherichia coli MG1655 strains to produce long chain fatty acids by engineering fatty acid synthesis (FAS) metabolism
Keywords: E. coli MG1655; Fatty acid biosynthesis; Long chain fatty acid; Acetyl-CoA; Malonyl-CoA; Malonyl-[acp]; Fatty acyl-ACP chain
Deficiencies in acetyl-CoA carboxylase and fatty acid synthase 1 differentially affect eggshell formation and blood meal digestion in Aedes aegypti
Keywords: Lipogenesis; Metabolism; Gonotrophic cycle; Malonyl-CoA; RNAi
Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA
Keywords: Escherichia coli; Metabolic network modeling; Malonyl-CoA; OptForce; Synergistic effect; Flavonoids
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats
Keywords: Acetyl-CoA carboxylase; Malonyl-CoA; Ligand lipophilicity efficiency; Quinoline
Coenzyme A and its thioester pools in fasted and fed rat tissues
Keywords: Coenzyme A; Acetyl-CoA; Malonyl-CoA; Rats; Brain; CoA metabolism
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
Keywords: Malonyl-CoA; Malonyl-CoA decarboxylase (MCD); Acetyl-CoA; Acetyl-CoA carboxylase (ACC); Fatty acid synthase (FAS); Fatty acid oxidation (FAO); Diabetes; Obesity; Glucose oxidation
Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats
Keywords: Malonyl-CoA; NPY; AgRP; CART; POMC;
Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae)
Keywords: Carnitine palmitoyltransferase; Fatty acid oxidation; Lipid metabolism; Arthropod; Crustacean; Prawn; Mitochondria; Carnitine; Malonyl-CoA
Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering
Keywords: Malonyl-CoA; Metabolic engineering; Polyketides; Flavonoids; Type III polyketide synthases
Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscle
Keywords: PPARγ; PPARα agonists; Rosiglitazone; Fenofibrate; Malonyl-CoA; Malonyl-CoA decarboxylase; Acetyl-CoA carboxylase
Effects of dietary fatty acid composition on the regulation of carnitine palmitoyltransferase (CPT) I in rainbow trout (Oncorhynchus mykiss)
Keywords: Carnitine palmitoyltransferase I; Diet; Malonyl-CoA; Membrane composition; Mitochondria; Peroxisome proliferator activated receptor; Polyunsaturated fatty acids; Rainbow trout
Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice
Keywords: C75; Gastric emptying; Gastrointestinal transit; Malonyl-CoA; Ghrelin
Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs onmitochondrial energy metabolism
Keywords: CoA; coenzyme A; KGDHc; alpha-ketoglutarate dehydrogenase complex; PDHc; pyruvate dehydrogenase complex; DBH; decylubihydroquinone; TCA; tricarboxylic acid; SMOAA; short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs; GCDH; glutaryl-CoA de
Intertissue regulation of carnitine palmitoyltransferase I (CPTI): Mitochondrial membrane properties and gene expression in rainbow trout (Oncorhynchus mykiss)
Keywords: Carnitine palmitoyltransferase I; Enzyme inhibition; Mitochondria; Membrane composition; Malonyl-CoA
Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply
Keywords: Acetyl-CoA carboxylase; Malonyl-CoA; Polyketides; Heterologous expression; Precursor supply
Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors
Keywords: Trifluoroacetyl; Trifluoroacetophenone; Malonyl-CoA; Acetyl-CoA; Malonyl-CoA decarboxylase; MCD; Fatty acid oxidation; Glucose oxidation
Dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters
Keywords: CoA; Malonyl-CoA; Acetyl-CoA; Succinyl-CoA; Phosphatase; Intracellular pools
cDNA cloning of a BAHD acyltransferase from soybean (Glycine max): Isoflavone 7-O-glucoside-6â³-O-malonyltransferase
Keywords: Soybean; Glycine max; Leguminosae; Malonyltransferase; Acyltransferase; Malonyl-CoA; BAHD; Isoflavone; Isoflavonoid; Glucoside; Malonylglucoside;
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
Keywords: Malonyl-CoA; Acetyl-CoA; Malonyl-CoA decarboxylase; MCD; Fatty acid oxidation; Glucose oxidation
Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors
Keywords: Malonyl-CoA; Acetyl-CoA; Malonyl-CoA decarboxylase; MCD
Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide
Keywords: Myxobacteria; Precursor feeding; Malonyl-CoA; Acetyl-CoA; 13C labelling
Quantification of malonyl-coenzyme A in tissue specimens by high-performance liquid chromatography/mass spectrometry
Keywords: Malonyl-CoA; HPLC; Electrospray ionization; Mass spectrometry
Sensing the fat: Fatty acid metabolism in the hypothalamus and the melanocortin system
Keywords: AGRP; Fatty acids; Fatty acid synthase; Feeding; Malonyl-CoA; Obesity; POMC
Structure and regulation of acetyl-CoA carboxylase genes of metazoa
Keywords: Gene structure; Transcription; AMP-activated protein kinase; Lipogenesis; β-oxidation; Malonyl-CoA; Biotin; Insulin resistance; Membrane targeting; Alternative splicing; Pseudogene;