کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378368 981999 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of apoptosis by a novel indirubin-5-nitro-3′-monoxime, a CDK inhibitor, in human lung cancer cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Induction of apoptosis by a novel indirubin-5-nitro-3′-monoxime, a CDK inhibitor, in human lung cancer cells
چکیده انگلیسی

A novel indirubin analog, indirubin-5-nitro-3′-monoxime, inhibited cell proliferation against various human cancer cells. Additional studies indicate that the mechanism of action of this analog against human lung cancer cells might be to arrest cell cycle progression at the G2/M phase and induce apoptosis via p53- and mitochondria-dependent pathways. These data suggest that indirubin-5-nitro-3′-monoxime might be a novel candidate for development of anticancer agents.

A novel indirubin analog, indirubin-5-nitro-3′-monoxime, inhibited cell proliferation against various human cancer cells. Additional studies indicate that the mechanism of action of this analog against human lung cancer cells might be to arrest cell cycle progression at G2/M phase and induce apoptosis via p53- and mitochondria-dependent pathways.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 17, 1 September 2005, Pages 3948–3952
نویسندگان
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