کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378464 | 982001 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents](/preview/png/1378464.png)
چکیده انگلیسی
Maintaining a proper balance of metal concentrations is critical to the survival of bacteria. We have designed and synthesized a series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to achieve bacterial killing. Biological studies showed that two of the compounds had very significant antimicrobial effect with an MIC value of 7.8 μg/mL against Gram-positive Bacillus subtilis.
A series of efflux substrate–metal chelator conjugates was developed as potential antimicrobial agents.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 3, 1 February 2007, Pages 707–711
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 3, 1 February 2007, Pages 707–711
نویسندگان
Yanling Zhang, C. Eric Ballard, Shi-Long Zheng, Xingming Gao, Ko-Chun Ko, Hsiuchin Yang, Gary Brandt, Xinhui Lou, Phang C. Tai, Chung-Dar Lu, Binghe Wang,