Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers

C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (ΔTm) of 18.8 °C after incubation of 36 h at 37 °C.

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