کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378503 982002 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A structural screening approach to ketoamide-based inhibitors of cathepsin K
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A structural screening approach to ketoamide-based inhibitors of cathepsin K
چکیده انگلیسی

Several novel ketoamide-based inhibitors of cathepsin K have been identified. Starting from a modestly potent inhibitor, structural screening of P2 elements led to 100-fold enhancements in inhibitory activity. Modifications to one of these leads resulted in an orally bioavailable cathepsin K inhibitor.

Several novel ketoamide-based inhibitors of cathepsin K have been identified. Starting from a modestly potent inhibitor, structural screening of P2 elements led to 100-fold enhancements in inhibitory activity. Modifications to one of these leads resulted in an orally bioavailable cathepsin K inhibitor.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 9, 2 May 2005, Pages 2209–2213
نویسندگان
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