NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives

The enantiopure 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives 4 were evaluated for their affinity to the ifenprodil binding site of the NMDA receptor, their potency to inhibit [3H]MK801 binding, their NMDA-NR2B subtype selectivity and their affinity to HERG K+ channels.