کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378658 982006 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential
چکیده انگلیسی

Pinusolide (1), a known platelet-activating factor (PAF) receptor binding antagonist, was synthesized from lambertianic acid (2), a labdane-type diterpene readily accessible in multigram quantities from the Siberian pine tree. It was shown that 1 not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 μM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. Also, using primary lymphoblasts and leukemic cells from children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), a significant DNA fragmentation in pinusolide-treated cells could be detected in an ex vivo apoptosis assay.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 16, 15 August 2006, Pages 4228–4232
نویسندگان
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