کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1378778 | 982009 | 2005 | 6 صفحه PDF | دانلود رایگان |
Eight new camphorato platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against HL-60 human leukemia, 3AO human ovarian carcinoma, BEL-7402 human hepatocarcinoma, and A549 human lung carcinoma cell lines. Most complexes showed good cytotoxic activity against the above-selected cell lines. Among the complexes, two compounds were assayed for their in vivo antitumor activity against LS-174T human colon carcinoma cells implanted in mice. One complex exhibited not only higher in vivo antitumor activity, but also less toxicity than oxaliplatin when it was administered intravenously at a dose of 6 mg/kg three times.
Eight new camphorato platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against four human tumor cell lines. The antitumor activities of compounds 3a and b were assayed in vivo against LS-174T human colon carcinoma cell line. Complex 3b exhibited not only higher in vivo antitumor activity, but also less toxicity than oxaliplatin when it was administered intravenously three times at a dose of 6 mg/kg.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 14, 15 July 2005, Pages 3417–3422