کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378810 | 982010 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro](/preview/png/1378810.png)
چکیده انگلیسی
A native glycopeptide, LZ-D-4, was purified from the fruiting bodies of Ganoderma lucidum, and its derivative, LZ-D-9, was prepared using sulfated agent (CSA: Pyr = 1:6). HPLC experiment showed that both of them were homogeneity and had molecular weights of 1.56 Ã 104 and 1.30 Ã 104 Da, respectively. Some properties including amino acid and monosaccharide compositions were investigated for the two compounds, along with anti-tumour bioactivity in vitro. The results indicated that two monosaccharides (Xyl and Ara) were completely destroyed and most of amino acids in LZ-D-4 were broken during sulfated process. Anti-tumour test in vitro showed that both complexes have properties to inhibit growth of L1210 cell lines and have similar bioactivities, but might have different mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 77, Issue 2, 10 June 2009, Pages 276-279
Journal: Carbohydrate Polymers - Volume 77, Issue 2, 10 June 2009, Pages 276-279
نویسندگان
LiBin Ye, JingSong Zhang, Shuai Zhou, Sheng Wang, Di Wu, YingJie Pan,