کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378825 982010 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives
چکیده انگلیسی

The paper reports the preparation, characterization and potential biological activities of a chemically sulfated polysaccharide isolated from Phellinus ribis. Four sulfated derivatives (PRP-SI–IV) with variable degrees of substitution were obtained by the chlorosulfonic acid method, without degradation of the polysaccharide (PRP). The sulfate groups were not regularly distributed along the polysaccharide chain with a multiple substitution pattern as determined by 13C NMR. The sulfated derivatives except for PRP-SI showed significant inhibition effects on HepG2 cells in comparison with the native non-sulfated polysaccharide (PRP). All sulfated derivatives could block new angiogenic vessel formation in zebrafish assay, however, the effects were less than PRP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 77, Issue 2, 10 June 2009, Pages 370–375
نویسندگان
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