Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines

A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 μM).

A series of substituted quinoxalines (29 compounds) was synthesized and evaluated against several protozoa. Some of them showed promising antileishmanial activity against Leishmania donovani.Figure optionsDownload as PowerPoint slide