Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands

The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.

We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NF-κB transcriptional activity but are devoid of conventional estrogenic activity.Figure optionsDownload as PowerPoint slide