Piperazinyl oxime ethers as NK-1 receptor antagonists

The synthesis and structure–activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.

The synthesis and SAR for a new class of centrally active NK-1 receptor antagonists are described. The new compounds all have a piperazinyl oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.Figure optionsDownload as PowerPoint slide