Keywords: نورو کینین; Opioids; Analgesia; Adverse effects; Mechanisms; Constipation; Nausea; Vomiting; Respiratory depression; 5-HT; 5-hydroxytryptamine; 7TMRs; 7-transmembrane spanning G-protein coupled receptors; AC; adenylyl cyclase; β-arr1; β-arrestin1; β-arr2; β-arres
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Keywords: نورو کینین; ANOVA; analysis of variance; BHR; bronchial hyperresponsiveness; E; effect; EFS; electrical field stimulation; EC50; concentration inducing 50% Emax; Emax; maximal effect; iNOS; inducible nitric oxide synthase; NKA; neurokinin A; NKn receptor; neurokinin
Keywords: نورو کینین; 6MWT; 6-min walk test; GOLD; Global Initiative for Chronic Obstructive Lung Disease; IC; inspiratory capacity; IPF; idiopathic pulmonary fibrosis; LABA; long-acting β-agonist; LAMA; long-acting muscarinic antagonist; mMRC; modified Medical Research Counc
Keywords: نورو کینین; D-SP; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P; SP; substance P; NE; norepinephrine; NK1-R; neurokinin 1 receptor; β1-AR; β1-adrenergic receptor; Ventricular arrhythmias; Acute myocardial infarction; Neurokinin; Neurokinin-1 receptor; β1-Adrenergi
The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models
Keywords: نورو کینین; Neurokinin; Alcohol; Intermittent access; Striatum; Escalation;
Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases
Keywords: نورو کینین; GPCR; cAMP; receptor internalization; TSH; LH; endosomal signaling; G protein-coupled receptor; (GPCR); protein kinase A; (PKA); cyclic adenosine monophosphate; (cAMP); mitogen-activated protein kinase; (MAPK); thyroid stimulating hormone; (TSH); parathyr
Substance P receptor in the rat indusium griseum during postnatal development
Keywords: نورو کینین; AHC; Anterior hippocampal continuation; cc; corpus callosum; Cg2; Cingulate cortex, Area 2; CPu; Caudate-putamen nucleus; gcc; Genu of the corpus callosum; GCL; Granular cell layer; IG; Indusium griseum; LV; Lateral ventricle; ML; Medial molecular layer;
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation
Keywords: نورو کینین; ACh; acetylcholine; BLA; basolateral amygdala; BNST; bed nucleus of stria terminalis; CeA; central nucleus of amygdala; CPU; caudate-putamen; CPP; conditioned place preference; DA; dopamine; dPAG; dorsal part of the periaqueductal gray matter; EPM; elevat
Inhibition of substance P-induced defensive behavior via neurokinin-1 receptor antagonism in the central and medial but not basolateral nuclei of the amygdala in male Wistar rats
Keywords: نورو کینین; ANOVA; analysis of variance; SP; substance P; Sal; saline; Span; spantide; NK; neurokinin; CeA; central nucleus of the amygdala; MeA; medial nucleus of the amygdala; BLA; basolateral nucleus of the amygdala; EPM; elevated plus maze; USV; ultrasonic vocali
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate
Keywords: نورو کینین; NK; neurokinin; SP; substance P; GPCR; G protein-coupled receptor; CNS; central nervous system; SAD; social anxiety disorders; CINV; chemotherapy-induced nausea and vomiting; PoC; prove of concept; SAR; structure-activity relationship; CDI; carbonyldiim
Tacr1 Gene Variation and Neurokinin 1 Receptor Expression Is Associated with Antagonist Efficacy in Genetically Selected Alcohol-Preferring Rats
Keywords: نورو کینین; Alcohol; amygdala; neurokinin; P-rat; self-administration; Substance P
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Keywords: نورو کینین; Neurokinin A; NK1/NK2 receptor interaction; Brain; Mouse; DMSO; dimethyl sulfoxide; FW; face washing/head scratching; HG; hind limb grooming/biting; ICV; intracerebroventricular(ly); NK; neurokinin; NK1Râ/â mice; NK1 receptor knock-out mice; NKA; neur
Role of tachykinin and neurokinin receptors in the regulation of ovine omasal contractions
Keywords: نورو کینین; Neurokinin; Non-cholinergic; Contraction; Omasum; Sheep;
Stress and visceral pain: From animal models to clinical therapies
Keywords: نورو کینین; ASICs; acid-sensing ion channels; BDNF; brain-derived neutrophic factor; ATP; adenosine triphosphate; CB; cannabinoid; CeA; central amygdala; CNS; central nervous system; CRD; colorectal distension; CRF; corticotropin releasing factor; CRF1; CRF receptor
Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids
Keywords: نورو کینین; 5-HT; 5-hydroxytryptamine; n; adenosine receptor; AT; angiotensin receptor; BZD; benzodiazepine; B2; bradykinin receptor; CGRP; calcitonin gene related peptide; CB; cannabinoid receptor; CCK; cholecystokinin; Dn; dopamine receptors; EHNA; erythro-9-(2-hyd
Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs
Keywords: نورو کینین; Neurokinin; Antagonist; Luteinizing hormone; Testicular toxicity; Dog
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway
Keywords: نورو کینین; Neurokinin; Neurokinin 1 receptor; Neuroprotection; 6-OHDA; Parkinson's disease; PD; Parkinson's disease; SN; substantia nigra; 6-OHDA; 6-hydroxydopamine; Akt/PKB; Akt/Protein kinase B; NK; neurokinin; CNS; central nervous system; TH; tyrosine hydroxy
Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder
Keywords: نورو کینین; Nitro-fatty acid; Afferent nerve; Transient receptor potential vanilloid receptor 1; Transient receptor potential acrylin receptor 1; Neurokinin
Neurokinin3-R agonism in aged rats has anxiolytic-, antidepressant-, and promnestic-like effects and stimulates ACh release in frontal cortex, amygdala and hippocampus
Keywords: نورو کینین; Aging; Neurokinin; NK3 receptor agonist; Episodic-like memory; Open field; Forced swimming test; Anxiety; Antidepressant-like; In vivo microdialysis; Acetylcholine
Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity
Keywords: نورو کینین; Neurokinin; NK2; Acetylcholine; In vivo microdialysis; Medial septal area; Temporal-order memory; Place memory; Object memory; Vehicle effects;
Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor
Keywords: نورو کینین; Neurokinin; Neurokinin-1 antagonists; Functional IP
Pharmacological characterization of senktide-induced tail whips
Keywords: نورو کینین; Neurokinin; Tachykinin; Tail rattling; In vivo assay; Mouse; Antipsychotic
Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues
Keywords: نورو کینین; Alcoholism; Reward; Opioids; Pharmacogenetics; Stress; Anxiety; Amygdala; Corticotropin-releasing hormone; Substance P; Neurokinin
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception
Keywords: نورو کینین; hyperalgesia; substance P; neurokinin; complete Freund's adjuvant; capsaicin; mustard oilCFA, complete Freund's adjuvant; Ipl, intraplantar; MO, mustard oil; NGC, nucleus reticularis gigantocellularis; NK-1, neurokinin-1; PWL, paw withdrawal latency; PWT,
New quinoline NK3 receptor antagonists with CNS activity
Keywords: نورو کینین; Neurokinin; NK3 receptor antagonist; Quinoline
The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion
Keywords: نورو کینین; Pineal; Substance P; Norepinephrine; Arylalkylamine N-Acetyltransferase; Melatonin; Tachykinin; Neurokinin
Differential mRNA splicing and precursor processing of neurokinin B in neuroendocrine tissues
Keywords: نورو کینین; Neurokinin; Tachykinin; Splice variant; Precursor; Pre-eclampsia
The role of neuro-immune cross-talk in the regulation of inflammation and remodelling in asthma
Keywords: نورو کینین; ACH; acetylcholine; AHR; airway hyperresponsiveness; α-MSH; alpha-melanocyte-stimulating hormone; BDNF; brain-derived neurotrophic factor; BALF; broncho-alveolar lavage fluid; CGRP; calcitonin gene-related peptide; DC; dendritic cell; EMTU; epithelial-me
Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6
Keywords: نورو کینین; Calcium; G protein-coupled receptor; Gut; insect; Neurokinin; Neuropeptide; Nervous system
Cholera Toxin Induces Sustained Hyperexcitability in Submucosal Secretomotor Neurons in Guinea Pig Jejunum
Keywords: نورو کینین; ACh; acetylcholine; AH; after hyperpolarization; APs; action potentials; CFTR; cystic fibrosis transmembrane conductance regulator; CT; cholera toxin; CT-B; B-subunit of cholera toxin; ENS; enteric nervous system; EPSPs; excitatory postsynaptic potentials
Basic and clinical aspects of gastrointestinal pain
Keywords: نورو کینین; ACC; anterior cingulated cortex; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; ANS; autonomic nervous system; CGRP; calcitonin gene-related peptide; CCK; cholecystokinin; CRH; corticotrophin-releasing hormone; CS; central sensitisation; ENS
Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells
Keywords: نورو کینین; Substance P; Neurokinin; Mastoparan; Cryptide; Peritoneal mast cell; Exocytosis; β-Hexosaminidase; [Ca2+]i increase; G protein
The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils
Keywords: نورو کینین; Gerbil; Senktide; Neurokinin; Tachykinin; Locomotor activity; Talnetant; SB223412; Osanetant; SR142801; SB222200; MK869; Aprepitant; Antipsychotic
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses
Keywords: نورو کینین; CS-003; Neurokinin; Tachykinin; Triple neurokinin receptor antagonist; Capsaicin; Cough
Long-lasting descending and transitory short-term spinal controls on deep spinal dorsal horn nociceptive-specific neurons in response to persistent nociception
Keywords: نورو کینین; Bee venom; Descending control; Nociceptive-specific neurons; Wide-dynamic range neurons; Neurokinin; Nociception
Design, synthesis, and structure–affinity relationship studies in NK1 receptor ligands based on azole-fused quinolinecarboxamide moieties
Keywords: نورو کینین; Neurokinin; NK1 receptor; Substance P; Synthesis; Amide derivatives
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction
Keywords: نورو کینین; Asthma; exercise-induced bronchoconstriction; epithelial cell; goblet cell; mucin; AREG; Amphiregulin; AUC; Area under the FEV1 time curve; cysLT; Cysteinyl leukotriene; DTT; Dithiothreitol; EGF; Epidermal growth factor; EIB; Exercise-induced bronchoconst
A formulation comparison, using a solution and different nanosuspensions of a poorly soluble compound
Keywords: نورو کینین; NK receptor; Neurokinin; Nanosuspensions; Pharmacokinetic
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists
Keywords: نورو کینین; Gerbil foot tap; Neurokinin; Senktide; Tachykinin receptor; Tachykinin receptor antagonist
Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors
Keywords: نورو کینین; NK; neurokinin; SP; substance P; NKA; neurokinin A; Pro7NKB; [Pro7]-neurokinin B; ASMSP; acetyl-[Arg6,Sar9,Met(O2)11]-SP6-11; NK1R; neurokinin 1 receptor; gNK1R; gerbil neurokinin 1 receptor; hNK1R; human neurokinin 1 receptor; rNK1R; rat neurokinin 1 rec
Piperazinyl oxime ethers as NK-1 receptor antagonists
Keywords: نورو کینین; Neurokinin; Synthesis; SAR; Oxime ethers
Novel lactam NK1 antagonists with anti-emetic activity
Keywords: نورو کینین; NK1; Neurokinin; Tachykinin; Substance P; Emesis; Anti-emetic; Lactam
Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides
Keywords: نورو کینین; Tachykinin; Hemokinin; Neurokinin; Processing; Peptide
Substance P receptor mediated maintenance of chronic inflammation in EAE
Keywords: نورو کینین; Substance P; Neurokinin; Neuropeptide; EAE; SR140333; MS
Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor
Keywords: نورو کینین; CRF1 receptor; corticotropin-releasing factor receptor; MAPK; mitogen-activated protein kinase; NK; neurokinin; NK-1-R; neurokinin-1 receptor; PKC; protein kinase C; SP; substance P; Affective disorder; Depression; HPA axis; Somatostatin receptor type 4;
Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret
Keywords: نورو کینین; Ferret; Cisplatin; Emesis; Ondansetron; Neurokinin; NK-3; SB-222200;
No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes
Keywords: نورو کینین; NK; neurokinin; NK-1-R; neurokinin-1 receptor; NK-1-RA; neurokinin-1 receptor antagonist; SP; substance P; Affective disorders; Depression; Therapy; Etiology; 5-HT; Reuptake;
Functional analysis of synthetic insectatachykinin analogs on recombinant neurokinin receptor expressing cell lines
Keywords: نورو کینین; Agonist; Calcium; Evolution; Insect; Neurokinin; Neuropeptide; Peptide; Pharmacology; Tachykinin; Receptor;
Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples
Keywords: نورو کینین; Dopamine; D2; Serotonin; 5-HT2A; Neurokinin; NK-1; Receptor occupancy; In vivo binding; Liquid chromatography; Mass spectroscopy; Haloperidol; Clozapine; Olanzapine; MK-869; Raclopride; MDL-100907; GR205171; Rat; Gerbil;
The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms
Keywords: نورو کینین; Circadian; Suprachiasmatic; Neurokinin; Raphe; Depression;