Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?

► Selective NK2 receptor agonists do not elicit behavioural effects in the brain. ► NK1 receptors are essential for generating central actions induced by NKA. ► High-affinity NK2 receptor antagonist inhibits behavioural effects induced by NKA. ► A NK1/NK2 receptor cross-talk mediates NKA actions in the brain.