کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574666 1129706 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides
چکیده انگلیسی

The endokinins represent several species-divergent and peripherally located mammalian tachykinins (hemokinin-1 in mouse and rat, endokinin-1 in rabbit and endokinins A and B in humans) and also the tachykinin gene-related peptides. These peptides are all encoded on the preprotachykinin 4 (TAC4) gene. Their complementary DNA sequences, gene structures and expression profiles have been determined from a number of different mammalian species. They are all flanked by adjacent upstream and downstream dibasic cleavage sites in their respective precursor proteins, except for human EKA/B that instead possesses a N-terminal monobasic cleavage site. Evidence for differential processing in the periphery at the N-terminal cleavage site of the tachykinins could explain why in humans the evolutionary pressure to maintain the N-terminal dibasic cleavage site of EKA/B has been lost. Furthermore, the TAC4 encoded tachykinins all exhibit a remarkable selectivity and potency for the highly species conserved tachykinin NK1 receptor, similar to that of substance P. Particular consideration is also given to the potential interactions of the endokinins with the short NK1 receptor isoform and to speculation of whether there could be an “endokinin-sensitive” NK1 binding site.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 45, Issue 4, October 2006, Pages 200–208
نویسندگان
,