کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379378 982027 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
چکیده انگلیسی

Fluoroalkyl and fluoroaryl analogues of valdecoxib were found to possess potent inhibitory activities against cyclooxygenase-2 comparable to that of the parent valdecoxib. Among them, the fluoromethyl analogue was chosen for 18F-labeling. Thus, 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide (∼2000 Ci/mmol at end of synthesis) was synthesized by [18F]fluoride-ion displacement of the corresponding tosylate in ∼40% decay-corrected radiochemical yield within ∼120 min from end of bombardment.

The [18F]fluoromethyl analogue of valdecoxib (∼2000 Ci/mmol) was synthesized by [18F]fluoride-ion displacement of the corresponding tosylate in ∼40% decay-corrected radiochemical yield within ∼120 min from end of bombardment.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4699–4702
نویسندگان
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