کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379384 982027 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel C2–C3′ N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3′
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel C2–C3′ N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3′
چکیده انگلیسی

A series of novel docetaxel analogues possessing a peptide side chain at the C3′-N position was synthesized. These compounds were designed to mimic a region of the α-tubulin loop that is equivalent to the paclitaxel binding pocket in β-tubulin. Eight new peptidic taxoids were obtained and evaluated as inhibitors of microtubule disassembly, as well as for their cytotoxicity.

The synthesis and biological activities of docetaxel analogues possessing a peptide side chain at the C3′-N position are described. The chosen amino acids are part of the α-tubulin loop that is equivalent to the paclitaxel binding pocket in β-tubulin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4722–4726
نویسندگان
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