کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1379384 | 982027 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel C2–C3′ N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3′
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A series of novel docetaxel analogues possessing a peptide side chain at the C3′-N position was synthesized. These compounds were designed to mimic a region of the α-tubulin loop that is equivalent to the paclitaxel binding pocket in β-tubulin. Eight new peptidic taxoids were obtained and evaluated as inhibitors of microtubule disassembly, as well as for their cytotoxicity.
The synthesis and biological activities of docetaxel analogues possessing a peptide side chain at the C3′-N position are described. The chosen amino acids are part of the α-tubulin loop that is equivalent to the paclitaxel binding pocket in β-tubulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4722–4726
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4722–4726
نویسندگان
Anne-Laure Larroque, Joëlle Dubois, Sylviane Thoret, Geneviève Aubert, Daniel Guénard, Françoise Guéritte,