کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1383158 1500621 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled release of acetylsalicylic acid from polythiophene/carrageenan hydrogel via electrical stimulation
ترجمه فارسی عنوان
آزادی کنترل اسید استیلسالیسیلیک از هیدروژل پلی یوفن / کاراژین با استفاده از تحریک الکتریکی
کلمات کلیدی
هیدروژل کاراژین، پلیتیفن، اسید استیلسالیسیلیک، ضریب انتشار، انتشار الکتریکی کنترل شده
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Fabrication of transdermal patch using PTh/carrageenan blend hydrogel.
• Drug was released by Fickian diffusion mechanism.
• Diffusion coefficient depended on crosslinking ratio or crosslinking ionic radii.
• Diffusion coefficients were greater with the applied electrical potentials.
• Diffusion coefficients with PTh as the drug carrier were higher than without PTh.

Blends between polythiophene (PTh) and a carrageenan hydrogel were fabricated as the matrix for the electric field assisted drug release. The pristine carrageenan and the blend films were prepared by the solution casting using acetylsalicylic acid (ASA) as the anionic model drug and Mg2+, Ca2+, and Ba2+ as the crosslinking agents. The ASA was released by the Fickian diffusion mechanism. The diffusion coefficient decreased with increasing crosslinking ratio or decreasing crosslinking ionic radii. The diffusion coefficients were greater with the applied electrical potentials by an order of magnitude relative to those without electric field. Moreover, the diffusion coefficients with PTh as the drug carrier were higher than those without PTh. Thus, the presence of the conductive polymer in the hydrogel blend coupled with applied electric field is shown here to drastically enhance the drug delivery rate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 137, 10 February 2016, Pages 214–221
نویسندگان
, , ,