A new method testing the orthogonality of different protecting groups

• A method was developed to identify orthogonality of various protecting groups.
• The method is based on the chemo-selectivity of protecting groups.
• The crude reaction mixtures were analysed by HPLC.
• With the method a new deprotection protocol for the propagyl group is developed.

A new test was elaborated to identify a new set of orthogonal protecting groups. With the developed method eight different protecting groups were tested under various deprotection conditions and the complex reaction mixtures were analysed by HPLC. The developed method allows for quick identification of orthogonality using simple model structures.

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